Cell-Based Assays
For cardiac safety or drug discovery projects, we can test your compounds in state-of-the-art electrophysiology and contractility assays using HEK cells, primary cardiomyocytes or hiPSC-derived cardiomyocytes.
Isolated Tissue
It is well appreciated that acquired or drug induced torsades de pointe (TdP), is associated with the generation of long action potential duration (APD)-related early after depolarizations (EADs) and EAD-induced triggered activity. EADs, ocurring as oscillations during phase 2 or 4 of the action potential (AP) are potentially arrhythmogenic.
