by Linden Schwark | Feb 10, 2020 | Research
Feng Wei, Marc Pourrier, David G Strauss, Norman Stockbridge, Li Pang Published: 10 February 2020 Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great potential for personalized cardiac safety prediction, particularly for that of...
by IonsGate Preclinical Services | Jan 21, 2020 | Research
By Marc Pourrier and David Fedida Published: 19 January 2020 Abstract: There is a need for improved in vitro models of inherited cardiac diseases to better understand basic cellular and molecular mechanisms and advance drug development. Most of these diseases are...
by IonsGate Preclinical Services | Aug 16, 2019 | Research
Cellular models developed to better predict proarrhythmic liability of drug candidates include commercially-available human stem cell-derived cardiomyocytes (hiPSC-CM) obtained from healthy subjects. Cardiac safety assessment, however, should not be limited to...
by IonsGate Preclinical Services | Feb 7, 2019 | Research
Cellular models developed to better predict proarrhythmic liability of drug candidates include commercially-available human stem cell-derived cardiomyocytes (hiPSC-CM) obtained from healthy subjects. Cardiac safety assessment, however, should not be limited to...
by IonsGate Preclinical Services | Oct 6, 2016 | Research
If you missed Dr Pourrier’s presentation on the late sodium current (late INa) at the last SPS meeting in Vancouver (18-21 September 2016), you can download it here: Your Name (required) Your Email (required) [recaptcha]...
by IonsGate Preclinical Services | Nov 19, 2015 | Research
Introduction The voltage-gated sodium channel Nav1.5 is highly expressed in cardiac myocytes. Depolarization causes these channels to open briefly, allowing a large entry of Na+ ions that peaks within ~ 2-3 ms and further depolarizes the cell to generate the upstroke...
