by IonsGate Preclinical Services | Nov 19, 2015 | Research
Introduction The voltage-gated sodium channel Nav1.5 is highly expressed in cardiac myocytes. Depolarization causes these channels to open briefly, allowing a large entry of Na+ ions that peaks within ~ 2-3 ms and further depolarizes the cell to generate the upstroke...
by IonsGate Preclinical Services | Nov 19, 2015 | Research
Rationale: Diastolic dysfunction can lead to heart failure with preserved ejection fraction, for which there is no effective therapeutic. Ranolazine has been reported to reduce diastolic dysfunction, but the specific mechanisms of action are unclear. The effect of...
