Animal Models

Animal Models

Arrhythmia Model A limitation of the ICH-S7B guideline is that it specifically addresses repolarization delay with its well-known limitations to predict proarrhythmia risk and TdP. As a result of growing evidence against the use of QT interval as the primary endpoint...
Tissue-Based Assays- Purkinje fiber

Tissue-Based Assays- Purkinje fiber

Purkinje fiber assay It is well appreciated that acquired or drug induced-torsade de pointes (TdP), is associated with the generation of long action potential duration (APD)-related early after depolarizations (EADs) and EAD-induced triggered activity. EADs, occurring...
Ion channel and contractility assays

Ion channel and contractility assays

hERG is only really the beginning…CiPA is coming Current practice in cardiac safety pharmacology has been successful in preventing proarrhythmia- related post approval drug withdrawal. However, many challenges remain in the assessment of cardiac effects of new drugs....